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KMID : 0617219950060010078
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Duksung Bulletin Phamaceutical Sciences
1995 Volume.6 No. 1 p.78 ~ p.81
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Synthesis of 1-Amino-2-thio-3-aralkyl-5-methyl-4-imidazolidinones
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Kwon, Soon-Kyoung
Jung, Hae-Won/Park, Myung-Sook
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Abstract
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1-Amino-2-thio-3-aralkyl-5-methyl-4-imidazolidinones 5a-d were prepared in good yields by the reaction of aralkyl isothiocyanates with ethyl 2-hydrazinopropionate monohydrochloride 3 in the presence of triethylamine. The intermediates, N-amino-N-ethoxycarbonylethyl-N′-aralkylthioureas 4a-d, in the conversion of 3 to 5, were isolated and characterized. This method provides a convenient route to 3, 5-substituted 1-aminothiohydantoins.
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